Design of base-discriminating fluorescent (BDF) nucleobase for SNP typing

Highly selective fluorescent nucleobases for designing base-discriminating fluorescent probes*

There is increasing interest in single nucleotide polymorphism (SNP) typing since they can be used as markers to identify the genes that underlie complex diseases and to realize the full potential of pharmacogenomics in analyzing variable response to drugs. Among the different methodologies for SNP genotyping, the homogenous assay is more amenable than the heterogeneous one. In this article, we...

Fluorescent nucleobase analogues for base–base FRET in nucleic acids: synthesis, photophysics and applications

Förster resonance energy transfer (FRET) between a donor nucleobase analogue and an acceptor nucleobase analogue, base-base FRET, works as a spectroscopic ruler and protractor. With their firm stacking and ability to replace the natural nucleic acid bases inside the base-stack, base analogue donor and acceptor molecules complement external fluorophores like the Cy-, Alexa- and ATTO-dyes and ena...

investigating the feasibility of a proposed model for geometric design of deployable arch structures

deployable scissor type structures are composed of the so-called scissor-like elements (sles), which are connected to each other at an intermediate point through a pivotal connection and allow them to be folded into a compact bundle for storage or transport. several sles are connected to each other in order to form units with regular polygonal plan views. the sides and radii of the polygons are...

A comparison of two informative SNP-based strategies for typing

Design of a Multiplier for Similar Base Numbers Without Converting Base Using a Data Oriented Memory

One the challenging in hardware performance is to designing a high speed calculating unit. The higher of calculations speeds in a computer system  will be pointed out in terms of performance. As a result, designing a high speed calculating unit is of utmost importance. In this paper, we start design whit this knowledge that one multiplier made of several adder and one divider made of several su...